- symmetrical double cutaway plain maple body, two f-holes, single-ply creme top and back binding, one-piece 1959-style rounded mahogany neck with long neck tenon, 22-fret bound rosewood fingerboard with pearloid dot inlays, holly headstock veneer, Roy Orbison signature engraved on truss rod cover, full color Roy Orbison stamp on back of headstock, three-per-side Vintage tulip tuners, ABR-1 bridge, TP-6 tailpiece, raised layered black pickguard, two '57 Classic humbucker pickups, four black knobs (two v, two tone), three-way pickup switch, nickel hardware, available in Antique Ebony finish, 16 in. body width, 19 in. body length, 1.75 in. body depth, 24.75 in. scale, limited edition run of approx. 270 instruments, mfg. 2006-07.

There were two separate releases on the ES-335 Roy Orbison. The first series consisted of 70 instruments and was released to commemorate his 70th birthday. These guitars are serial numbered RO 0XX and are often referred to as "Pilot 70." The second series consisted of 200 instruments and are serial numbered ROY XXX.

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